Spike Protein Cleavage-Activation in the Context of the SARS-CoV-2 P681R Mutation: an Analysis from Its First Appearance in Lineage A.23.1 Identified in UgandaArticle Published on 2022-08-312022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] A.23.1 activated Activation Affect Alpha variant analyzed appearance arginine B.1.1.7 B.1.617 B.1.617.2 cell-cell fusion change changes changes in cleavability cleavage Context Course delta variant functional functional consequences furin furin cleavage site host cell Identified increase in infectivity assay less Lineage mimicking Mutation natural selection notable occur occurred P681R P681R mutation pandemic Particle Pathogenesis peptide performed position 681 predicted proline protease pseudotyped S1/S2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike significantly increased spike spike gene Spike protein Spike. Spread Surveillance the SARS-CoV-2 Transmissibility transmitted Uganda variant viral variant virus virus [DOI] 10.1128/spectrum.01514-22 PMC 바로가기
Furin cleavage of the SARS-CoV-2 spike is modulated by O -glycosylationSARS-COV-2 스파이크의 푸린 절단은 O- 글리코 실화에 의해 조절된다.407 Published on 2021-11-032022-08-13 Journal: Proceedings of the National Academy of Sciences of [Category] Biochemistry, COVID-19, SARS, [키워드] O- abrogate Alpha alpha and delta variants Amino acid amino acids cells circumvent cleavage coronavirus decrease delta variant Delta variants dependent on expressed family members furin furin cleavage furin cleavage of S furin cleavage site GALNT GALNT enzyme global pandemic glycosylating S glycosylation highlight host O -glycosylation host-mediated O -glycosylation human respiratory cell human respiratory cells increase insertion insertion site modulated modulating Mutation O -glycosylation P681 P681 mutation P681 mutations position position 681 proline pseudoviral infectivity respiratory responsible resulting SARS-CoV-2 coronavirus SARS-COV-2 infection shown Significance spike Spike protein syncytia formation target targets the SARS-CoV-2 the spike protein tropism unique Viral viral infectivity viral infectivity/tropism [DOI] 10.1073/pnas.2109905118 PMC 바로가기 [Article Type] 407